Home Tools
Log in
Cart

Search Result

Search Results for " dihydrofolate reductase "

20

Compounds

Cat No. Product Name Synonyms Targets
T3693 DHFR-IN-3 7-bromoquinazoline-2,4-diamine Others
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.
T6120 Pralatrexate Folotyn,10-Propargyl-10-deazaaminopterin Apoptosis , DHFR , Antifolate , TAM Receptor
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...
T1153 Trimethoprim NIH 204,BW 56-72,NSC-106568 DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...
T24962 10-Formylfolic acid DHFR
10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.
T19858 Brodimoprim DHFR , Antibacterial
Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.
T0849 Pyrimethamine Pirimecidan,RP 4753,Pirimetamin DHFR , Antifolate , Parasite
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T17257L WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Others
WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...
T25886 Methotrexate Diglutamate NSC-269401,NSC 269401,NSC269401 DHFR
Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.
T24644 Piritrexim BW 301U DHFR
Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma and metastatic breast cancer.
T61486 DHFR-IN-4 DHFR
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.
T7730 Aminopterin APGA,4-Aminofolic acid Antifolate
Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
T5420 Cycloguanil hydrochloride Chloroguanide Triazine Parasite , Drug Metabolite
Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, r...
T1485 Methotrexate NCI-C04671,WR19039,Amethopterin,CL14377 Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...
T36692 Fanotaprim DHFR
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...
T20339 7-Hydroxymethotrexate NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 Drug Metabolite
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin...
T64295 Talotrexin ammonium DHFR
Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, he...
T4382 Proguanil hydrochloride Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T30761 CB 3703 CB3703,NSC 289522,CB-3703
CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase.
T17164 Trimetrexate CI-898 Others
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.
T23883 Chlorasquin Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861
Chlorasquin is a dihydrofolate reductase inhibitor.

Compounds

DHFR-IN-3
T3693
Synonym: 7-bromoquinazoline-2,4-diamine
Target: Others
Pralatrexate
T6120
Synonym: Folotyn,10-Propargyl-10-deazaaminopterin
Target: Apoptosis, DHFR, Antifolate, TAM Receptor
Trimethoprim
T1153
Synonym: NIH 204,BW 56-72,NSC-106568
Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic
10-Formylfolic acid
T24962
Synonym:
Target: DHFR
Brodimoprim
T19858
Synonym:
Target: DHFR, Antibacterial
Pyrimethamine
T0849
Synonym: Pirimecidan,RP 4753,Pirimetamin
Target: DHFR, Antifolate, Parasite
WR99210 hydrochloride(47326-86-3 free base)
T17257L
Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
Target: Others
Methotrexate Diglutamate
T25886
Synonym: NSC-269401,NSC 269401,NSC269401
Target: DHFR
Piritrexim
T24644
Synonym: BW 301U
Target: DHFR
DHFR-IN-4
T61486
Synonym:
Target: DHFR
Aminopterin
T7730
Synonym: APGA,4-Aminofolic acid
Target: Antifolate
Cycloguanil hydrochloride
T5420
Synonym: Chloroguanide Triazine
Target: Parasite, Drug Metabolite
Methotrexate
T1485
Synonym: NCI-C04671,WR19039,Amethopterin,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Fanotaprim
T36692
Synonym:
Target: DHFR
7-Hydroxymethotrexate
T20339
Synonym: NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962
Target: Drug Metabolite
Talotrexin ammonium
T64295
Synonym:
Target: DHFR
Proguanil hydrochloride
T4382
Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil
Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite
CB 3703
T30761
Synonym: CB3703,NSC 289522,CB-3703
Target:
Trimetrexate
T17164
Synonym: CI-898
Target: Others
Chlorasquin
T23883
Synonym: Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861
Target:
1 2 3
TargetMol